I have hit both and I own the DNA. I sell Demarini's locally so I have an Insane to swing as well. I was torn between the two but ended up going with the DNA (26 oz midload, stiff handle, weighs 27 on the scale with tape). My biggest complaint about the DNA is the sweetspot being so small. If you hit the sweetspot though there is really not much that can compete with it.
The Insane is end loaded but it doesn't feel very end loaded when I swing it. The barrel is soft but it has a big sweetspot. I think the Insane is easier to hit with since the sweetspot is so much bigger but the DNA provides better performance IMO. In the end you can't go wrong with either one.